APHINITY | AACR Cancer Research | Frontier Science Scotland

APHINITY | Journal of the National Cancer Institute (JNCI)

May 5, 2022

Impact of age on clinical outcomes and efficacy of adjuvant dual anti-HER2 targeted therapy

APHINITY | European Journal of Cancer (EJC)

Mar 18, 2022

Six-year absolute invasive disease-free survival benefit of adding adjuvant pertuzumab to trastuzumab and chemotherapy for patients with early HER2-positive breast cancer: A Subpopulation Treatment Effect Pattern Plot (STEPP) analysis of the APHINITY (BIG 4-11) trial

The ALTTO Trial: Updated Results from the international phase III ALTTO trial (BIG2-06/Alliance N063D)

May 1, 2021

Presentation of the pre-specified analyses of >5-years follow-up of the Phase III ALTTO trial as shown at the 2017 annual meeting of the American Society of Clinical Oncology and published in the European Journal of Cancer in 2021.

The APHINITY Trial: Results of the Interim Overall Survival Analysis at 6 years’ follow-up

May 1, 2021

The JCO confirms the invasive disease-free survival benefit from adding pertuzumab to standard adjuvant therapy for patients with node-positive HER2-positive early breast cancer.

A pooled analysis of the Cardiac Events in three adjuvant trials: HERA, NSBAP B-31, and NCCTG 9831 (Alliance Trials)

Jan 1, 2020

Breast Cancer Research and Treatment published that Adjuvant trastuzumab should be considered a safe treatment from a cardiac standpoint for most patients. Further research is needed to individualize prevention and management of trastuzumab-associated cardiotoxicity.

The APHINITY Trial: Results of the Primary Analysis

Jul 13, 2017

An article published in the New England Journal of Medicine (NEJM) reports that pertuzumab, when added to chemotherapy and trastuzumab, significantly improved the rates of invasive-disease–free survival among patients with HER2-positive early breast cancer.

The HERA Trial: Final Analysis Results

Feb 16, 2017

An article published in The Lancet shares the results from the final analysis of the HERceptin Adjuvant (HERA) trial.

The NordICC Study: Population-based colonoscopy screening for colorectal cancer: a randomized clinical trial.

Jul 1, 2016

JAMA Internal Medicine reports on the investigation into participation rates, adenoma yield, performance, and adverse events of population-based colonoscopy screening in several European countries.

The ALTTO Trial: Results of the Primary Analysis

Apr 1, 2016

An article in the JCO reports that adjuvant treatment that includes lapatinib did not significantly improve Disease-Free Survival compared with trastuzmab alone and added toxicity. One year of adjuvant trastuzumab remains standard of care.

The Neo-ALTTO Trial: Pathological complete response after neoadjuvant anti-HER2 therapy

Sep 1, 2014

Findings from this study confirm that patients who achieve pathological complete response after neoadjuvant anti-HER2 therapy have longer event-free and overall survival than do patients without pathological complete response.