The EPoS (European Polyp Surveillance) study is a group of related randomised controlled clinical trials which aim to address the optimum colonoscopy surveillance interval for patients who have had premalignant polyps identified and removed from the large bowel, in order to determine the most effective surveillance programme for the prevention of colorectal cancer. Over 20,000 participants from a selection of European countries are assigned to one of three EPoS trials depending on the characteristics of their presenting polyps (categorised as high risk, low risk or serrated polyps), following a clinical colonoscopy.

In collaboration with the University of Oslo, Frontier Science designed the randomisation method, developed the eCRF data collection system, and is responsible for ongoing clinical database management, data management and reporting. In addition Frontier Science has recently adapted the randomisation parameters, eCRF data collection system and data management, to incorporate an additional prospective, observational study including patients with cancer polyps removed at colonoscopy, into the portfolio.

OTHER PROJECTS

HERA

HERA

The HERA trial influenced changes in the standard of care for those with HER2-positive breast cancer. Find out more about the study design and our involvement >>

NordICC

NordICC

Colorectal cancer (CRC) is major burden in western countries which develops over a long time-interval from precursor lesions which exist in the colon. Colonoscopy can detect and remove the precursor lesions and may therefore be an effective intervention for the...

FINESSE

FINESSE

Frontier Science has worked in partnership with the Breast International Group (BIG), Breast European Adjuvant Study Team (BrEAST) and in collaboration with Institut de Recherches Internationales SERVIER on the FINESSE trial. The trial was an open, 3-cohort, phase II...

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Frontier Science Scotland provides adaptable solutions across data management and biostatistics for clinical trials. To find out more, get in touch.

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