FLAIR | British Journal of Haematology

FLAIR | British Journal of Haematology

OVERVIEW Front-Line therapy in CLL: Assessment of Ibrutinib-containing Regimens (FLAIR) demonstrated improved progression-free survival for ibrutinib and rituximab (IR) compared with fludarabine, cyclophosphamide and rituximab (FCR) in previously untreated chronic...
COLONIZE | Annals of Internal Medicine

COLONIZE | Annals of Internal Medicine

OVERVIEW Fecal microbiota transplantation (FMT) is recommended for recurrent Clostridioides difficile infection (CDI), but its role in primary CDI is unclear. The study compared FMT without antibiotic pretreatment versus oral vancomycin, 125 mg 4 times daily for 10...
APHINITY | European Journal of Cancer

APHINITY | European Journal of Cancer

OVERVIEW Nearly half of patients in the APHINITY trial were overweight/obese. Overweight/obesity was associated with poorer survival outcomes. Higher chemotherapy discontinuation rates were found in patients with overweight/obesity. Obesity remained linked to poorer...
ALTTO | ESMO Open

ALTTO | ESMO Open

OVERVIEW Dual anti-human epidermal growth factor receptor 2 (HER2) blockade has improved the outcomes of patients with early and metastatic HER2-positive breast cancer. The final 10-year analysis of the ALTTO trial is presented here. study details The Adjuvant...