COLONIZE | Annals of Internal Medicine

COLONIZE | Annals of Internal Medicine

OVERVIEW Fecal microbiota transplantation (FMT) is recommended for recurrent Clostridioides difficile infection (CDI), but its role in primary CDI is unclear. The study compared FMT without antibiotic pretreatment versus oral vancomycin, 125 mg 4 times daily for 10...
APHINITY | European Journal of Cancer

APHINITY | European Journal of Cancer

OVERVIEW Nearly half of patients in the APHINITY trial were overweight/obese. Overweight/obesity was associated with poorer survival outcomes. Higher chemotherapy discontinuation rates were found in patients with overweight/obesity. Obesity remained linked to poorer...
ALTTO | ESMO Open

ALTTO | ESMO Open

OVERVIEW Dual anti-human epidermal growth factor receptor 2 (HER2) blockade has improved the outcomes of patients with early and metastatic HER2-positive breast cancer. The final 10-year analysis of the ALTTO trial is presented here. study details The Adjuvant...
APHINITY | Journal of Clinical Oncology

APHINITY | Journal of Clinical Oncology

OVERVIEW The human epidermal growth factor receptor 2 (HER2) is the second most important target for systemic breast cancer (BC) therapy after the estrogen receptor. HER2 overexpression is found in 15%-20% of patients with BC. Today, HER2-directed therapies are...