Learn how Frontier science scotland partnered with the University of Oslo for the nordicc study
In collaboration with the University of Oslo, FSS held responsibility for trial data collection, management and cleaning processes. After inheriting the original Case Report Form (CRF) system from a third party we used Coloreg, an application for Electronic Data Capture (EDC), to consolidate five databases and to create secure remote access for our sites via our server.
Throughout the trial, some specific tasks included:
- merging the five non-identical databases into a single consolidated database
- removal of personally identifiable information (PII)
- data standardisation across multiple languages, e.g. code lists
- streamlining the invitation process for partners.
Study Details
The Nordic-European Initiative on Colorectal Cancer (NordICC) study is a multinational, population-based randomized clinical trial set up to investigate the effectiveness of colonoscopy screening on colorectal cancer incidence and mortality in several European countries.
Colorectal cancer (CRC) is major burden in western countries which develops over a long time-interval from precursor lesions which exist in the colon. Colonoscopy can detect and remove the precursor lesions and may, therefore, be an effective intervention for the prevention of CRC. The NordICC study is a randomised controlled trial which compares a study group, who are offered a one-time screening colonoscopy, with a control group who follow the current standard of care.
The aim of the study is to address the efficacy of population colonoscopy screening on reducing CRC incidence and mortality after 15 years of follow up.
KEY STUDY OUTCOMES
Results of the original investigation were published in JAMA Internal Medicine in 2016: Population-Based Colonoscopy Screening for Colorectal Cancer: A Randomized Clinical Trial.
